Innate Immune Memory for Improved Vaccine Response
نویسندگان
چکیده
Abstract Emerging diseases require generating new vaccines, which can often be time-consuming. An alternate method to boost host defense is by inducing nonspecific innate immune memory, called trained immunity, develop novel prophylactics. Many molecules, most notably β-glucan, induce but their effects are short-lived and uncontrolled. This lack of temporal control limits both the therapeutic ability training provides fundamental questions about its nature. To improve on capabilities we developed a for immunity examined use as prophylactic an additive vaccine outcomes. We engineered controlled release nanoparticles encapsulating only 3.5% standard dose β-glucan attain sustained over month. Nanoparticle mice exhibited prolonged improved resistance B16F10 tumor challenge compared that received equivalent amount free β-glucan. also showed higher antibody responses upon vaccination. These results demonstrate dosing substantially alter response unanticipated levels. As such, this approach using platforms might lead strategy disease against wide variety diseases. HDTRA11810052
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.223.10